Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study

Background: Brain imaging results in sleep deprived patients showed structural changes the cerebral cortex; however, reasons for this phenomenon need to be further explored. Methods: This MR study evaluated causal associations between morningness, ease of getting up, insomnia, long sleep, short and cortex structure. Results: At functional level, morningness increased surface area (SA) cuneus with global weighted (beta(b) (95% CI): 32.63 (10.35, 54.90), p = 0.004). Short SA lateral occipital (b 394.37(107.89, 680.85), 0.007. reduced cortical thickness (TH) paracentral (OR −0.11 (−0.19, −0.03), 0.006). TH parahippocampal −0.25 (−0.42, −0.07), No pleiotropy was detected. However, none Bonferroni-corrected values relationship structure five types traits met threshold. Conclusions: Our potentially show evidence a higher risk association neuropsychiatric disorders not only brain areas atrophy, but also an increase middle temporal zone. findings shed light on occurrence traits.